Interleukin-23 and T helper 17-type responses in intestinal inflammation: from cytokines to T-cell plasticity
نویسندگان
چکیده
منابع مشابه
Interleukin-23 drives innate and T cell–mediated intestinal inflammation
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract involving aberrant activation of innate and adaptive immune responses. We have used two complementary models of IBD to examine the roles of interleukin (IL)-12 family cytokines in bacterially induced intestinal inflammation. Our results clearly show that IL-23, but not IL-12, is essential for the i...
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interleukin (il)-17-producing t helper (th)-17 cells have recently been explained as a distinct population of cd4+ t cells which play an important role in immunity against infectious agents. establishment of persistent phenotype of th17 cells and recognition of lineage-deviating factors are of most attractive goals in modern researches in immunology. although il-6 and tgf-β are freque...
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Interleukin-23 (IL-23) is essential for the differentiation of pathogenic effector T helper 17 (Th17) cells, but its role in memory Th17 cell responses is unclear. Using the experimental autoimmune encephalomyelitis (EAE) model, we report that memory Th17 cells rapidly expanded in response to rechallenge and migrated to the CNS in high numbers, resulting in earlier onset and increased severity ...
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1Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany 2Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany 3Department of Immunology and Microbial Disease, Albany Medical Center, Albany, NY, USA 4Istituto Nazionale di Genetica Molecolare Romeo ed Enrica Invernizzi, Milan, Italy 5Gastroen...
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Background: Preeclampsia is a common pregnancy-specific disorder associated with significant maternal and fetal morbidity and mortality worldwide. It has been proposed that the imbalance between two CD4+ T cell subtypes, regulatory T cells (Treg) and T-helper 17 cells (Th17), is involved in the pathophysiology of preeclampsia. Objectives: To determine the serum levels of IL-17, IL-21, IL-23 and...
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ژورنال
عنوان ژورنال: Immunology
سال: 2011
ISSN: 0019-2805
DOI: 10.1111/j.1365-2567.2011.03454.x